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The experimental animal facility plays an important role in the substitution of clinical trail. Animal room is classified as significance system that conducts on stabilizing experiment.

• Inside the building Type
• Container Type

In accordance with GLP(Good Laboratory Practice), it is necessary to follow the standards when conducting animal experiments. The strict regulations are need for verifying the validity of experiments in the medical substance.

FDA have implemented a law to regulate stability assessment since 1979. In addition, legislation about GLP has been enacted by authorities of Japan in 1983. GLP’s standard includes managing animal experiments, regulating a structure of animal room.

Animals Category		mouse	Rats	Hamster	Marmot		Rabbit	Monkey	Cat	Dog
Temperature		20 ~ 26℃				18 ~ 28℃
Humidity		(To be not less than 30%, 70% or more) from 40 to 60%
Cleanliness		class 10,000 (Barrier zone is not breeding animals)
Cleanliness	Dust	class 10,000 (Barrier zone is not breeding animals)
	Drop bacteria	3 Below(Barrier zone is not breeding animals)
	30 Below	30 Below (Animal breeding areas not normally)
	Smell	Does not exceed the ammonia concentration 20ppm
Flow rate		13~18㎝/sec
Like		5mmH2O increases in static pressure difference. Higher 15mmH2O (SPF barrier zone) at constant pressure difference (isolators)
		150pa higher than the static pressure difference around the hall (Isolrator)
Ventilation frequency		6 to 15 times / h (depending on the supply and exhaust change method)
Roughness		150 ~ 300 Lux (bottom 40 ~ 85 cm)
Noise		Does not exceed 60 dB (A) to

- Class nine minutes of the classification of NASA
- Kord 9cm diameter opening 30 minutes (blood agar 48 h)

Category	Temperature(℃)	Humidity(％)	Weight(g)	Occupied space(㎥)	Ventilation(㎥/h)
Mice	18~26	40~60	22	9.62*10-4	0.25
Hamster	18~26	40~70	120	1.87*10-3	0.7
Rabbit	18~21	40~60	~3600	0.116	21
Cat	18~29	30~70	~3700	0.17	21
mouse	18~26	40~70	250	3.34*10-3	1.4
Dog	18~29	30~70	~22,700	1.27	128
Primates	18~29	30~70	~5450	0.283	31

References animal kind	ASHRAE		Animal Research Facility		G.L.P
	Temperature (℃ DB)	Humidity (% RH)	Temperature (℃ DB)	Humidity (% RH)	Temperature (℃ DB)	Humidity (% RH)
Mouse	18 ~ 26	40 ~ 70	20 ~ 26	40 ~ 60	20 ~ 26	46 ~ 60
Rat	18 ~ 26	40 ~ 70	20 ~ 26	40 ~ 60	20 ~ 26	46 ~ 60
Hamster	18 ~ 26	40 ~ 70	20 ~ 26	40 ~ 60	20 ~ 26	46 ~ 60
Marmot	18 ~ 26	40 ~ 70	20 ~ 26	40 ~ 60	20 ~ 26	46 ~ 60
Rabbit	16 ~ 21	40 ~ 45	18 ~ 28	40 ~ 60	18 ~ 28	46 ~ 60
Cat	18 ~ 29	40 ~ 45	18 ~ 28	40 ~ 60	18 ~ 28	46 ~ 60
Dog	18 ~ 29	40 ~ 55	18 ~ 28	40 ~ 60	18 ~ 28	46 ~ 60
Primates	18 ~ 29	40 ~ 60	18 ~ 28	40 ~ 60	18 ~ 28	46 ~ 60

- ASHRAE : Handbook, 1982 Applications , 1982, p.14. 14
- Laboratory Animal Research Facility Based on Laboratory Animal Facilities Construction and Equipment Guide Line, 1983

Geupbyeol	Particle				Biological particles
	Diameter(um)		Cumulative particle (Pc / ℓ)		Part flow (improved / ℓ)		Precipitation amount (dog / ㎡)
	NASA	209B	NASA	209B	NASA	209B	NASA	209B
100	≥ 0.5	≥ 0.5	≥ 3.5	≥ 3.5	0.0035	0.0035	12,900	12,900
10,000	≥ 0.5	≥ 0.5	≤ 350	≤ 350	0.0176	0.0176	64,600	64,600
	≥ 5.0	≥ 5.0	≤ 2.3	≤ 2.3
100,000	≥ 0.5	≥ 0.5	≤ 3,500	≤ 3,500	0.0884	0.0884	323,000	323,000
	≥ 5.0	≥ 5.0	≤ 25	≤ 25

• Breeding room : Lighting is controlled automatically depending on day and night
• Vestibule : establishment of buffer zone
• Corridor : to facilitate movement / more than 1.3meters are needed
• Clean preparation room : sterilization room. high pressure steam sterilizers, and Pass box are installed
• Air shower area : Installed in accordance with regulations such as air attachment, air current, and inter lock etc
• Sterilization room : Installed with abrasion&chemical resistance materials to reduce contamination
• Operating room : It is common to install the asepsis operating room
• Recovery room : accessibility options

• Control temperature and moisture accurately by Hot Gas By Pass
• 24hours, 24steps, and 24sets are settable
• Constant wind speed
• Separated type shelves
• Classified as significance system that conducts on stabilizing experiment.